Journal Article

Ventriculitis Complicating Use of Intraventricular Catheters in Adult Neurosurgical Patients

K. E. Lyke, O. O. Obasanjo, M. A. Williams, M. O'Brien, R. Chotani and T. M. Perl

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 12, pages 2028-2033
Published in print December 2001 | ISSN: 1058-4838
Published online December 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/324492
Ventriculitis Complicating Use of Intraventricular Catheters in Adult Neurosurgical Patients

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Ventriculitis is a serious complication of intraventricular catheter (IVC) use, with rates of IVC-related infections ranging from 0% to 45% and gram-positive organisms predominating. We prospectively analyzed ventriculostomy-related infections occurring among 157 adult neurosurgical patients (mean age, 54.9 years; 90 [57%] were women) from 1995 through 1998, to determine the incidence of, risk factors for, and organisms that cause ventriculitis. A total of 196 IVC events resulted in 11 infections (5.6%; 9 were caused by gram-negative organisms and 2 by coagulase-negative staphylococci). Independent risk factors for IVC-related infection include length of IVC placement (8.5 days [infected] vs. 5.1 days [uninfected]; P = .007) and cerebrospinal fluid leakage about the IVC (P = .003). The length of hospital stay (30.8 days vs. 22.6 days; P = .03) and mean total hospital charges ($85,674.27 vs. $55,339.21; P = .009) were greater for infected patients than for uninfected patients. In addition, a microbiologic shift from gram-positive organisms toward gram-negative organisms was noted. This study suggests that IVC-related infections remain serious infections that increase the length of hospitalization.

Journal Article.  3852 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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