Journal Article

Regional Trends in Antimicrobial Resistance among Clinical Isolates of <i>Streptococcus pneumoniae, Haemophilus influenzae</i>, and <i>Moraxella catarrhalis</i> in the United States: Results from the TRUST Surveillance Program, 1999–2000

Clyde Thornsberry, Daniel F. Sahm, Laurie J. Kelly, Ian A. Critchley, Mark E. Jones, Alan T. Evangelista and James A. Karlowsky

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue Supplement_1, pages S4-S16
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/324525
Regional Trends in Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: Results from the TRUST Surveillance Program, 1999–2000

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The ongoing TRUST (Tracking Resistance in the United States Today) study, which began monitoring antimicrobial resistance among respiratory pathogens in 1996, routinely tracks resistance at national and regional levels. The 1999–2000 TRUST study analyzed 9499 Streptococcus pneumoniae, 1934 Haemophilus influenzae, and 1108 Moraxella catarrhalis isolates that were prospectively collected from 239 laboratories across the 9 US Bureau of the Census regions. Penicillin-resistant S. pneumoniae varied significantly by region, from 8.3% to 24.8% (P < .001). In each region, penicillin resistance closely predicted resistance to other β-lactams, macrolides, and trimethoprim-sulfamethoxazole. Levofloxacin resistance was 0.5% nationally (regional range, 0.1%–1.0%). Multidrug resistance also varied significantly (P < .001) by region. β-Lactamase production among H. influenzae varied significantly (regional range, 24.0%–34.6%) and M. catarrhalis (86.2%–96.8%) also varied by region. Notable variation in regional antimicrobial resistance rates (S. pneumoniae) and β-lactamase production (H. influenzae, M. catarrhalis) exists throughout the United States.

Journal Article.  5478 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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