Journal Article

Influence of Human Immunodeficiency Virus Type 1 Infection on Acute Hepatitis A Virus Infection

Setsuko Ida, Natsuo Tachikawa, Aya Nakajima, Manabu Daikoku, Michitami Yano, Yoshimi Kikuchi, Akira Yasuoka, Satoshi Kimura and Shinichi Oka

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 3, pages 379-385
Published in print February 2002 | ISSN: 1058-4838
Published online February 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338152
Influence of Human Immunodeficiency Virus Type 1 Infection on Acute Hepatitis A Virus Infection

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To assess the possible influence of human immunodeficiency virus type 1 (HIV-1) infection on the clinical course of acute hepatitis A virus (HAV) infection, 15 HIV-1–infected homosexual men and 15 non—HIV-infected age-matched subjects were compared. HAV load was higher in HIV-1–infected than in non—HIV-infected patients (P < .001). Duration of viremia in HIV-1–infected patients (median, 53 days) was significantly (P < .05) longer than in non—HIV-infected patients (median, 22 days). HIV-1–infected patients had lower elevations in alanine aminotransferase levels than did non—HIV-infected patients (P < .01) but had higher elevations in alkaline phosphatase levels than did non—HIV-infected patients (P < .001). Some HIV-1–infected patients still had HAV viremia when clinical symptoms had disappeared and alanine aminotransferase levels had returned to normal (60–90 days after the onset of symptoms). HIV-1 infection was associated with prolongation of HAV viremia, which might cause a long-lasting outbreak of HAV infection in HIV-1–infected homosexual men.

Journal Article.  4005 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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