Journal Article

Thrombocytopenia Associated with Linezolid Therapy

Kinan Attassi, Ellie Hershberger, Rabiul Alam and Marcus J. Zervos

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 5, pages 695-698
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338403
Thrombocytopenia Associated with Linezolid Therapy

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We evaluated the incidence and clinical characteristics of linezolid-induced thrombocytopenia in 19 patients who were treated with linezolid. Overall, thrombocytopenia (platelet count, µ100,000 platelets/mm3) was observed in 32% of patients who received linezolid for µ10 days; gastrointestinal bleeding was observed in 1 patient and 4 patients required platelet transfusions. These data suggest that even patients who are not considered to be at risk for development of thrombocytopenia should be monitored closely if linezolid therapy is continued for µ10 days.

Journal Article.  1013 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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