Journal Article

Disseminated Phaeohyphomycosis: Review of an Emerging Mycosis

Sanjay G. Revankar, Jan E. Patterson, Deanna A. Sutton, Renee Pullen and Michael G. Rinaldi

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 4, pages 467-476
Published in print February 2002 | ISSN: 1058-4838
Published online February 2002 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/338636
Disseminated Phaeohyphomycosis: Review of an Emerging Mycosis

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Disseminated phaeohyphomycosis is an uncommon infection caused by dematiaceous fungi, although the number of case reports about this infection has been increasing in recent years. A total of 72 cases are reviewed. Scedosporium prolificans is by far the most common cause. The presence of melanin in their cell walls may be a virulence factor for these fungi. The primary risk factor is decreased host immunity, although cases in apparently immunocompetent patients have been reported. Eosinophilia was seen in 11% of cases. Endocarditis is mostly reported on bioprosthetic valves, particularly those of porcine origin. The outcome of antifungal therapy remains poor, with an overall mortality rate of 79%. Special precautions taken for immunocompromised patients may help prevent exposure to fungi during the patients' period of greatest risk. The development of newer antifungal agents and combination therapy may hold promise in improving the management of these devastating infections in the future.

Journal Article.  5593 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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