Journal Article

Cross-Linked Fibrin in the Nasal Fluid of Patients with the Common Cold

Birgit Winther, Jack M Gwaltney, John E. Humphries and J. Owen Hendley

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 5, pages 708-710
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338716
Cross-Linked Fibrin in the Nasal Fluid of Patients with the Common Cold

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To determine whether adherent material found on the walls of the paranasal sinuses during common colds might be fibrin clot, we examined the nasal fluid (a surrogate for sinus secretion) of 11 young adults with experimentally induced rhinovirus colds and that of 4 control subjects for the presence of fibrin. The mean concentration (± the standard error) of insoluble fibrin (measured as D-dimer) in subjects with rhinovirus colds increased from a baseline level of 0.8 ± 0.4 µg/mL to a peak of 2.4 ± 0.7 µg/mL (P = .0008) on day 4 after inoculation of the virus, but the fibrin concentration remained at baseline levels in the 4 uninfected control subjects.

Journal Article.  1618 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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