Journal Article

Nosocomial Spread of the Integron-Located <i>veb-1</i>—Like Cassette Encoding an Extended-Spectrum β-Lactamase in <i>Pseudomonas aeruginosa</i> in Thailand

Delphine Girlich, Thierry Naas, Amornrut Leelaporn, Laurent Poirel, Michael Fennewald and Patrice Nordmann

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 5, pages 603-611
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338786
Nosocomial Spread of the Integron-Located veb-1—Like Cassette Encoding an Extended-Spectrum β-Lactamase in Pseudomonas aeruginosa in Thailand

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The β-lactamase gene content and epidemiology of ceftazidime-resistant Pseudomonas aeruginosa isolates (24% of the total number of P. aeruginosa isolates) were investigated at a University Hospital in Thailand during a 4-month period in 1999. Of 33 nonrepetitive clinical isolates, 31 produced a VEB-1—like clavulanic acid—inhibited extended-spectrum β-lactamase (ESBL). These isolates belonged to different pulsed-field gel electrophoresis types and subtypes. In 1 case, the blaVEB-1-like gene was plasmid located. The blaVEB-1-like genes were present as a gene cassette on class 1 integrons that varied in size and structure. In most cases, the veb-1 cassette was associated with an arr-2 cassette (rifampin resistance), aminoglycoside resistance gene cassettes, and an oxa-10—like cassette encoding a narrow-spectrum oxacillinase-type β-lactamase. The present study indicates that ESBLs may be endemic in P. aeruginosa and illustrates that integrons are efficient means for their spread.

Journal Article.  4328 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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