Journal Article

Nosocomial Bloodstream Infections among Human Immunodeficiency Virus–Infected Patients: Incidence and Risk Factors

Nicola Petrosillo, Pierluigi Viale, Emanuele Nicastri, Claudio Arici, Enrico Bombana, Alberto Casella, Francesco Cristini, Michele De Gennaro, Ferdinando Dodi, Andrea Gabbuti, Gianni Gattuso, Laura Irato, Paolo Maggi, Federico Pallavicini, Angelo Pan, Mario Pantaleoni and Giuseppe Ippolito

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 5, pages 677-685
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338813
Nosocomial Bloodstream Infections among Human Immunodeficiency Virus–Infected Patients: Incidence and Risk Factors

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To assess the incidence of nosocomial bloodstream infections (NBSIs) in human immunodeficiency virus (HIV)—infected patients, and to analyze the main associated risk factors, we performed a 1-year multicenter prospective study of patients with advanced HIV infection who were consecutively admitted to 17 Italian infectious diseases wards. As of May 1999, a total of 65 NBSIs (4.7%) occurred in 1379 admissions, for an incidence of 2.45 NBSIs per 1000 patient-days. Twenty-nine NBSIs were catheter-related bloodstream infections, with a rate of 9.6 central venous catheter—associated infections per 1000 device-days. Multivariate analysis indicated that variables independently associated with NBSIs included active injection drug use, a Karnofsky Performance Status score of µ40, presence of a central venous catheter, and length of hospital stay. Mortality rates were 24.6% and 7.2% among patients with and without NBSIs, respectively (P µ .00001). In the era of highly active antiretroviral therapy, NBSIs continue to occur frequently and remain severe and life-threatening manifestations.

Journal Article.  5406 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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