Journal Article

The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management

Tzou-Yien Lin, Luan-Yin Chang, Shao-Hsuan Hsia, Yhu-Chering Huang, Cheng-Hsun Chiu, Chuen Hsueh, Shin-Ru Shih, Ching-Chuan Liu and Mei-Hwan Wu

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue Supplement_2, pages S52-S57
Published in print May 2002 | ISSN: 1058-4838
Published online May 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338819
The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management

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The most recently discovered enterovirus, enterovirus 71 (EV71), is neurotropic and may cause severe disease and sudden death in children. In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 71 (91%) were <5 years old. EV71 was the primary agent in fatal cases of infection. Most of these patients died within 1–2 days of admission to the hospital. We hypothesize that EV71 directly attacks the central nervous system and causes neurogenic pulmonary edema and cardiac decompensation through the mechanism of sympathetic hyperactivity and inflammatory responses. Early recognition of risk factors and intensive care are crucial to successful treatment of this fulminant infection. After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it.

Journal Article.  2983 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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