Journal Article

Severe Demyelinating Myelopathy with Low Human T Cell Lymphotropic Virus Type 1 Expression after Transfusion in an Immunosuppressed Patient

Simona Ozden, Danielle Seilhean, Antoine Gessain, Jean-Jacques Hauw and Olivier Gout

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 6, pages 855-860
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338868
Severe Demyelinating Myelopathy with Low Human T Cell Lymphotropic Virus Type 1 Expression after Transfusion in an Immunosuppressed Patient

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We describe an immunosuppressed patient who developed myelopathy after transfusion with human T cell lymphotropic virus type 1–infected blood products during cardiac transplantation; immunoglobulins and fibrinogen deposition indicated disruption of the blood-brain barrier. The low degree of inflammation and virus expression suggests that demyelination may have been caused by an antibody- and complement-mediated process and by an alteration of the spinal cord microenvironment with activation of microglial cells and astrocytes.

Journal Article.  2860 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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