Journal Article

Antibiotic-Resistant Gram-Negative Organisms in Pediatric Chronic-Care Facilities

Karen Lidsky, Claudia Hoyen, Ann Salvator, Louis B. Rice and Philip Toltzis

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 6, pages 760-766
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/338957
Antibiotic-Resistant Gram-Negative Organisms in Pediatric Chronic-Care Facilities

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This study was designed to define the prevalence of colonization with antibiotic-resistant gram-negative bacilli among children residing in long-term care facilities and to determine the frequency of cross-colonization with these organisms. Pharyngeal and rectal specimens were obtained from subjects residing in 2 pediatric extended-care facilities and were processed to identify gram-negative organisms resistant to ceftazidime, gentamicin, meropenem, and piperacillin-tazobactam. Horizontal transmission was assessed by analyzing all resistant isolates by pulsed-field gel electrophoresis. Forty percent of subjects were colonized with ⩾1 resistant bacillus;>60% of organisms were resistant to ⩾2 of the antibiotics tested. Colonization was disproportionate among residents with a tracheostomy or other prosthesis. More than 65% of colonized subjects shared ⩾1 organism with another resident, with cross-colonization occurring among both enteric and nonenteric species. Children residing in chronic-care facilities represent a large reservoir for resistant bacilli. Such colonization may be amenable to simple barrier infection-control procedures.

Journal Article.  4388 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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