Journal Article

Rates of Postoperative Complications among Human Immunodeficiency Virus–Infected Women Who Have Undergone Obstetric and Gynecologic Surgical Procedures

Thomas A. Grubert, Daniela Reindell, Ralph Kästner, Bernd H. Belohradsky, Lutz Gürtler, Manfred Stauber and Olaf Dathe

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 6, pages 822-830
Published in print March 2002 | ISSN: 1058-4838
Published online March 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/339043
Rates of Postoperative Complications among Human Immunodeficiency Virus–Infected Women Who Have Undergone Obstetric and Gynecologic Surgical Procedures

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Clinical observations indicate that human immunodeficiency virus (HIV)–positive women experience more postoperative problems than do HIV-negative women. To obtain a better estimate of the individual risk of postoperative morbidity among HIV-infected women, and to determine which procedures pose the greatest risk, we performed a retrospective case-control study in which we assessed the outcomes after 235 obstetric and gynecologic surgical procedures. For purposes of comparison, an HIV-negative control patient was matched for each of the 235 surgical procedures performed, on the basis of the type of procedure and patient age. We found a significantly greater number of postoperative complications among the HIV-positive women. Higher complication rates occurred after abdominal surgery (odds ratio [OR], 3.6; P = .001) and curettage (OR, 7.7; P = .06). Among HIV-infected women, the risk of complications was associated with immune status. Antiretroviral therapy and standard perioperative antibiotic prophylaxis did not decrease the risk of complications. Indications for performing abdominal surgery and curettage on HIV-infected women should be carefully weighed against the potential risk of postoperative complications.

Journal Article.  4251 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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