Journal Article

The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus—Infected Persons in Clinical Trials

Sharon Mannheimer, Gerald Friedland, John Matts, Carroll Child and Margaret Chesney

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 8, pages 1115-1121
Published in print April 2002 | ISSN: 1058-4838
Published online April 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/339074
The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus—Infected Persons in Clinical Trials

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We prospectively studied long-term antiretroviral adherence patterns and their impact on biologic outcomes for human immunodeficiency virus (HIV)–infected participants in 2 randomized, multicenter clinical trials. For the period from baseline to month 12 of the study, participants who reported adherence levels of 100%, 80%–99%, and 0%–79% had plasma HIV RNA levels that decreased by 2.77, 2.33, and 0.67 log10 copies/mL, respectively (P < .001), whereas their CD4 counts increased by 179, 159, and 53 cells/mm3, respectively (P < .001). Adherence predicted nondetectable HIV RNA levels (<50 copies/mL) at 12 months of follow-up (P < .001). The HIV RNA level was nondetectable in 72% of participants who reported 100% adherence at all 4 follow-up visits, compared with 66%, 41%, 35%, and 13% of participants who reported 100% adherence at 3, 2, 1, or 0 follow-up visits, respectively (P < .001). Nonwhite race was associated with poorer adherence (P < .001), and older age was associated with better adherence (P < .001).

Journal Article.  4717 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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