Journal Article

Subtype-Dependent Response of Hepatitis B Virus during the Early Phase of Lamivudine Treatment

Bernhard Zöllner, Jörg Petersen, Peter Schäfer, Matthias Schröter, Rainer Laufs, Martina Sterneck and Heinz-Hubert Feucht

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 9, pages 1273-1277
Published in print May 2002 | ISSN: 1058-4838
Published online May 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/339959
Subtype-Dependent Response of Hepatitis B Virus during the Early Phase of Lamivudine Treatment

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We conducted a 12-month longitudinal investigation of the subtype-dependent response of hepatitis B virus (HBV) to lamivudine treatment in 43 consecutive patients with chronic hepatitis B. HBV subtype ayw appears to respond better to lamivudine monotherapy than does HBV subtype adw (P = .005). This might be the reason for the lower incidence of lamivudine-resistant strains observed in persons infected with HBV subtype ayw during follow-up.

Journal Article.  3282 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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