Journal Article

Influence of Serogroup on the Presentation, Course, and Outcome of Invasive Meningococcal Disease in Children in the Republic of Ireland, 1995–2000

C. Mary Healy, Karina M. Butler, E. O'Brian Smith, Owen P. Hensey, Bate Terence, Anne C. Moloney, Paul MacMahon, John Cosgrove and Mary T. Cafferkey

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 10, pages 1323-1330
Published in print May 2002 | ISSN: 1058-4838
Published online May 2002 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/340050
Influence of Serogroup on the Presentation, Course, and Outcome of Invasive Meningococcal Disease in Children in the Republic of Ireland, 1995–2000

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To test the hypothesis that the infecting meningococcal serogroup modulates the presentation, course, and outcome of invasive meningococcal disease (IMD), we performed a retrospective review of cases of IMD in 407 children from 2 tertiary referral centers and 2 regional centers in Ireland. Patients infected with serogroup C meningococci (n = 104) were older than those infected with serogroup B (n = 303; median, 2.5 vs. 1.5 years; P = .04); all other demographic and clinical parameters were similar for the 2 groups. Among serogroup B patients, mortality was 3.6% and morbidity was 10%; for serogroup C patients, mortality was 4.8% and morbidity was 12.5% (P = .81 and P = .76, respectively). Serogroup C—associated sequelae more often were multiple (P = .003). Despite the introduction of serogroup C conjugate vaccine into the routine immunization schedule of some countries, ongoing morbidity from IMD is anticipated, because group B disease was very similar to group C disease in this pediatric population.

Journal Article.  5147 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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