Journal Article

Nosocomial Bacteremia Caused by Antibiotic-Resistant Gram-Negative Bacteria in Critically Ill Patients: Clinical Outcome and Length of Hospitalization

Stijn Blot, Koenraad Vandewoude, Dirk De Bacquer and Francis Colardyn

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 12, pages 1600-1606
Published in print June 2002 | ISSN: 1058-4838
Published online June 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/340616
Nosocomial Bacteremia Caused by Antibiotic-Resistant Gram-Negative Bacteria in Critically Ill Patients: Clinical Outcome and Length of Hospitalization

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Population characteristics and outcomes were retrospectively compared for critically ill patients with nosocomial bacteremia caused by antibiotic-susceptible (AB-S; n = 208) or antibiotic-resistant (AB-R; n = 120) gram-negative bacteria. No significant differences in severity of illness and comorbidity factors were seen between groups. Patients with bacteremia caused by AB-R strains had a longer hospitalization before the onset of the bacteremia. The in-hospital mortality for patients with bacteremia caused by AB-S strains was 41.8%; for patients infected with AB-R strains, it was 45.0% (P = .576). A multivariate survival analysis demonstrated that older age (P = .009), a high-risk source of bacteremia (abdominal and lower respiratory tract; P = .031), and a high acute physiology and chronic health evaluation II-related expected mortality (P = .032) were independently associated with in-hospital mortality (P < .05). Antibiotic resistance in nosocomial bacteremia caused by gram-negative bacteria does not adversely affect the outcome for critically ill patients.

Journal Article.  3775 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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