Journal Article

Discordant Human Immunodeficiency Virus Type 1 Drug Resistance Mutations, Including K103N, Observed in Cerebrospinal Fluid and Plasma

K. T. Tashima, T. P. Flanigan, J. Kurpewski, S. M. Melanson and P. R. Skolnik

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 1, pages 82-83
Published in print July 2002 | ISSN: 1058-4838
Published online July 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/340865
Discordant Human Immunodeficiency Virus Type 1 Drug Resistance Mutations, Including K103N, Observed in Cerebrospinal Fluid and Plasma

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Discordant resistance mutations were seen in human immunodeficiency virus type 1 (HIV-1) isolated from specimens of blood and cerebrospinal fluid (CSF) obtained from 3 of 6 patients. To our knowledge, this is the first report of HIV-1 isolated from CSF harboring the K103N mutation, which confers resistance to the nonnucleoside reverse-transcriptase inhibitors, and this finding may indicate that virus in the CSF replicates independently from virus in the blood compartment.

Journal Article.  978 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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