Journal Article

Epidemiology of Invasive Group A <i>Streptococcus</i> Disease in the United States, 1995–1999

Katherine L. O'Brien, Bernard Beall, Nancy L. Barrett, Paul R. Cieslak, Arthur Reingold, Monica M. Farley, Richard Danila, Elizabeth R. Zell, Richard Facklam, Benjamin Schwartz and Anne Schuchat

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 3, pages 268-276
Published in print August 2002 | ISSN: 1058-4838
Published online August 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/341409
Epidemiology of Invasive Group A Streptococcus Disease in the United States, 1995–1999

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Severe invasive group A streptococcal (GAS) disease is believed to have reemerged during the past 10–20 years. We conducted active, laboratory, population-based surveillance in 5 US states (total population, 13,214,992). From 1 July 1995 through 31 December 1999, we identified 2002 episodes of invasive GAS (3.5 cases per 100,000 persons). Rates varied by age (higher among those <2 or ⩾65 years old), surveillance area, and race (higher among black individuals) but did not increase during the study period. The 5 most common emm types (1, 28, 12, 3, and 11) accounted for 49.2% of isolates; newly characterized emm types accounted for 8.9% of isolates. Older age; presence of streptococcal toxic shock syndrome, meningitis, or pneumonia; and infection with emm1 or emm3 were all independent predictors of death. We estimate that 9600–9700 cases of invasive GAS disease occur in the United States each year, resulting in 1100–1300 deaths.

Journal Article.  5416 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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