Journal Article

Comparative Analysis of Commercial Assays for the Detection and Quantification of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Plasma from Patients Infected with HIV-1 Subtype C

Craig J. Hoesley, Susan A. Allen, James L. Raper, R. Musonda, Yafen Niu, Feng Gao, Kathleen E. Squires and Grace M. Aldrovandi

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 3, pages 323-325
Published in print August 2002 | ISSN: 1058-4838
Published online August 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/341490
Comparative Analysis of Commercial Assays for the Detection and Quantification of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Plasma from Patients Infected with HIV-1 Subtype C

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The commercial assays commonly used to quantify plasma human immunodeficiency virus type 1 (HIV-1) RNA in clinical settings were designed to assess HIV-1 subtype B. We compared the performance of 4 commercial assays (Amplicor versions 1.0 and 1.5 [Roche]; Quantiplex [Chiron]; and NASBA HIV-1 RNA QT [Organon Teknika]) in detecting and quantifying HIV-1 RNA in plasma from HIV-infected persons from Zambia, an area where HIV-1 subtype C is predominant. Each assay detected plasma HIV-1 RNA, but they do not all measure statistically similar quantities of plasma HIV-1 RNA.>

Journal Article.  1894 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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