Journal Article

Association between Antimicrobial Resistance among Pneumococcal Isolates and Burden of Invasive Pneumococcal Disease in the Community

Julia Y Morita, Elizabeth R Zell, Richard Danila, Monica M Farley, James Hadler, Lee H Harrison, Lewis Lefkowitz, Arthur Reingold, Benjamin A Kupronis, Anne Schuchat and Cynthia G Whitney

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 4, pages 420-427
Published in print August 2002 | ISSN: 1058-4838
Published online August 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/341897
Association between Antimicrobial Resistance among Pneumococcal Isolates and Burden of Invasive Pneumococcal Disease in the Community

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Treatment of infections with drug-resistant strains of Streptococcus pneumoniae (pneumococcus) may fail; whether drug resistance is associated with an increase in the number of serious infections in the community is unknown. We evaluated the relationship between the proportion of antimicrobial-resistant S. pneumoniae isolates and the number of cases of invasive pneumococcal disease. Linear regression models included 1996 county-level data from 38 counties participating in the US Centers for Disease Control and Prevention's Active Bacterial Core Surveillance. Separate models evaluated hospitalized children aged <5 years, nonhospitalized children aged <5 years, adults aged 18–64 years, and adults aged >64 years. The proportion of isolates resistant to ⩾3 drug classes was associated with invasive disease in both hospitalized (P =.06) and nonhospitalized (P =.001) children. The proportion of multidrug-resistant pneumococcal isolates did not predict invasive cases among adults. The increasing prevalence of multidrug-resistant pneumococci among children may be leading to an increase in invasive disease

Journal Article.  4844 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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