Journal Article

Gastrointestinal Microflora Studies in Late-Onset Autism

Sydney M. Finegold, Denise Molitoris, Yuli Song, Chengxu Liu, Marja-Liisa Vaisanen, Ellen Bolte, Maureen McTeague, Richard Sandler, Hannah Wexler, Elizabeth M. Marlowe, Matthew D. Collins, Paul A. Lawson, Paula Summanen, Mehmet Baysallar, Thomas J. Tomzynski, Erik Read, Eric Johnson, Rial Rolfe, Palwasha Nasir, Haroun Shah, David A. Haake, Patricia Manning and Ajay Kaul

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue Supplement_1, pages S6-S16
Published in print September 2002 | ISSN: 1058-4838
Published online September 2002 | e-ISSN: 1537-6591 | DOI:
Gastrointestinal Microflora Studies in Late-Onset Autism

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Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridium not found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found. In gastric and duodenal specimens, the most striking finding was total absence of non—spore-forming anaerobes and microaerophilic bacteria from control children and significant numbers of such bacteria from children with autism. These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder.

Journal Article.  5964 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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