Journal Article

Selection of Cefoxitin-Resistant <i>Bacteroides thetaiotaomicron</i> Mutants and Mechanisms Involved in β-Lactam Resistance

Hong Fang, Charlotta Edlund, Carl Erik Nord and Maria Hedberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue Supplement_1, pages S47-S53
Published in print September 2002 | ISSN: 1058-4838
Published online September 2002 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/341920
Selection of Cefoxitin-Resistant Bacteroides thetaiotaomicron Mutants and Mechanisms Involved in β-Lactam Resistance

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The β-lactam antibiotics are the most widely used of all the groups of antimicrobials, but β-lactam resistance is increasingly common among members of the Bacteroides fragilis group. Three major mechanisms are involved in β-lactam resistance, and they act together in certain instances. In the present study, 2 resistant mutants (238m and 1186m) of Bacteroides thetaiotaomicron, obtained from clinical isolates (238 and 1186) by selection with increasing concentrations of cefoxitin, showed decreased susceptibilities to cefoxitin and other β-lactam antibiotics. Alterations in both penicillin-binding proteins (PBPs) and outer-membrane proteins (OMPs) were observed in the mutants in comparison with their parent strains. The similar alteration in OMPs was also observed in clinical isolates. In conclusion, the β-lactam—resistant mutants of B. thetaiotaomicron with deficiency in both PBPs and OMPs can be selected for by exposure to cefoxitin, and several mechanisms are involved in the β-lactam resistance in the strains investigated.

Journal Article.  4491 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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