Journal Article

Immune Reconstitution Syndrome after Successful Treatment of <i>Pneumocystis carinii</i> Pneumonia in a Man with Human Immunodeficiency Virus Type 1 Infection

Christine E Koval, Francis Gigliotti, Diana Nevins and Lisa M Demeter

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 4, pages 491-493
Published in print August 2002 | ISSN: 1058-4838
Published online August 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/341974
Immune Reconstitution Syndrome after Successful Treatment of Pneumocystis carinii Pneumonia in a Man with Human Immunodeficiency Virus Type 1 Infection

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We describe a 34-year-old man with human immunodeficiency virus infection who received successful treatment of minimally symptomatic Pneumocystis carinii pneumonia and who subsequently developed diffuse pulmonary infiltrates and hypoxia 2 weeks after initiation of combination antiretroviral therapy. Initial pathologic evaluation of lung-tissue samples revealed no organisms, but a polymerase chain reaction assay was strongly positive for P. carinii DNA. We hypothesize that this patient's clinical presentation denotes immune reconstitution syndrome in response to residual P. carinii antigen in the lung

Journal Article.  1913 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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