Journal Article

Indinavir-Induced Cholelithiasis in a Patient Infected with human Immunodeficiency Virus

Renaud Verdon, Michel Daudon, Françoise Albessard, Jean-Louis Brefort and Claude Bazin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 5, pages e57-e59
Published in print September 2002 | ISSN: 1058-4838
Published online September 2002 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/341982
Indinavir-Induced Cholelithiasis in a Patient Infected with human Immunodeficiency Virus

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We report the first case of acute cholecystitis due to indinavir-induced cholelithiasis in a patient infected with human immunodeficiency virus who had been receiving indinavir for 56 months. Infrared spectroscopy demonstrated that the gallstone was composed of indinavir monohydrate (50%), calcium bilirubinate (28%), calcium palmitate (10%), cholesterol (7%), and proteins (5%). The role of high-level chronic unconjugated hyperbilirubinemia coupled with high blood concentrations of indinavir is discussed.

Journal Article.  1829 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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