Journal Article

Human Immunodeficiency Virus (HIV)—Specific Antibody in Cervicovaginal Lavage Specimens Obtained from Women Infected with HIV Type 1

Selvi B. Williams, Timothy P. Flanigan, Susan Cu-Uvin, Kenneth Mayer, Pepper Williams, Christopher A. Ettore, Andrew W. Artenstein, Ann Duerr and Thomas C. VanCott

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 5, pages 611-617
Published in print September 2002 | ISSN: 1058-4838
Published online September 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/342201
Human Immunodeficiency Virus (HIV)—Specific Antibody in Cervicovaginal Lavage Specimens Obtained from Women Infected with HIV Type 1

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To evaluate correlates of anti-human immunodeficiency virus (HIV) type 1 (HIV-1) immunoglobulin (Ig) in the genital tract, anti-HIV-gp120 IgA and IgG titers in cervicovaginal lavage specimens obtained from 104 HIV-1-infected women were measured by enzyme-linked immunosorbent assay. Overall, 24% and 94% of women had detectable anti-gp120 IgA and IgG, respectively. CD4 cell count correlated negatively with total IgA concentration (r = −0.301; P = .0027) and positively with specific IgA activity (anti-gp120 IgA titer/total IgA concentration, r = 0.306; P = .0023). Women with bacterial vaginosis had 5-fold lower anti-gp120 IgG titer (P = .0042), 5-fold lower total IgG concentration (P ⩽ .0001), and 4-fold higher specific IgG activity (P = .0474) compared with women who did not have bacterial vaginosis. Enhanced understanding of correlates of mucosal immunity to HIV-1 may assist in the design of vaccine strategies or in the prevention of vertical transmission of HIV-1.

Journal Article.  4739 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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