Journal Article

<i>Pythium insidiosum</i> Pleuropericarditis Complicating Pneumonia in a Child with Leukemia

John A. Heath, Timothy E. Kiehn, Arthur E. Brown, Michael P. LaQuaglia, Laurel J. Steinherz, Gonzalo Bearman, May Wong and Peter G. Steinherz

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 6, pages e60-e64
Published in print September 2002 | ISSN: 1058-4838
Published online September 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/342303
Pythium insidiosum Pleuropericarditis Complicating Pneumonia in a Child with Leukemia

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We describe a 12-year-old boy with acute myeloid leukemia who developed pleuropericarditis while he was neutropenic and was receiving intravenously administered antibiotic and antifungal therapy for pneumonia. A KOH preparation of the purulent material from an extensive diagnostic and therapeutic pleuropericardial drainage procedure revealed multiple irregularly septate hyphae, and cultures yielded the organism Pythium insidiosum. After completing a 12-month course of intravenously administered liposomal amphotericin B (AmBisome; Fujisawa Healthcare) and itraconazole, the patient remained alive, in clinical remission, and symptom free.

Journal Article.  2330 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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