Journal Article

Review of the Effect of Highly Active Antiretroviral Therapy on Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus and HCV Coinfection

Curtis L. Cooper and D. William Cameron

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 7, pages 873-879
Published in print October 2002 | ISSN: 1058-4838
Published online October 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/342388
Review of the Effect of Highly Active Antiretroviral Therapy on Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus and HCV Coinfection

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The effect of anti—human immunodeficiency virus (HIV) treatment on hepatitis C virus (HCV) RNA levels in HIV-HCV—coinfected persons is uncertain. Although it is commonly believed that, with the initiation of HIV treatment, there may be an initial increase followed by a gradual decrease of HCV RNA levels to lower than those at pretreatment, the published studies evaluating this are of small and heterogeneous populations, are limited in follow-up, and have conflicting results. A prospective clinical trial of sufficient size and duration may help clarify this issue. This may be clinically relevant, because lower HCV RNA levels are a predictive factor for favorable response to HCV antiviral therapy.

Journal Article.  5221 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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