Journal Article

Human Herpesvirus 8–Positive Castleman Disease in Human Immunodeficiency Virus–Infected Patients: The Impact of Highly Active Antiretroviral Therapy

Laurent Aaron, Olivier Lidove, Cherine Yousry, Laurent Roudiere, Bertrand Dupont and Jean Paul Viard

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 7, pages 880-882
Published in print October 2002 | ISSN: 1058-4838
Published online October 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/342696
Human Herpesvirus 8–Positive Castleman Disease in Human Immunodeficiency Virus–Infected Patients: The Impact of Highly Active Antiretroviral Therapy

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We report the case histories of 7 human immunodeficiency virus (HIV)—infected patients receiving highly active antiretroviral therapy (HAART) who had a diagnosis of Castleman disease. All 6 patients who were treated responded to chemotherapy; immune reconstitution was observed in 5 patients, but it did not prevent relapse of Castleman disease. However, the mean duration of survival observed in this series (48 months) was most probably due to immune reconstitution resulting from receipt of HAART, which reduced the mortality associated with HIV disease.

Journal Article.  1838 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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