Journal Article

Detection of Hepatitis C Virus (HCV) RNA in Normal Cervical Smears of HCV-Seropositive Patients

Manavi Mahmood, Mehrdad Baghestanian, Watkins-Riedel Thomas, Walter Battistutti, Kerstin Pischinger, Christian Schatten, Eveline Witschko, Gernot Hudelist, Hanns Hofmann and Klaus Czerwenka

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 8, pages 966-973
Published in print October 2002 | ISSN: 1058-4838
Published online October 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/342909
Detection of Hepatitis C Virus (HCV) RNA in Normal Cervical Smears of HCV-Seropositive Patients

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The presence of hepatitis C virus (HCV) in normal cervical smears (CS) obtained from 22 HCV-seropositive and 50 HCV-seronegative patients was assessed by reverse-transcriptase-polymerase chain reaction (RT-PCR). The presence of HCV in serum was established by use of enzyme-linked immunosorbent assay, Western blot test, and RT-PCR. HCV was detected in 36.4% (n = 8) of CS cells recovered from 22 HCV-seropositive patients, but not in CS samples obtained from 50 HCV-seronegative patients. Furthermore, cells from the CS of 2 seropositive/smear-positive patients and 1 seropositive/smear-negative patient were isolated; HCV RNA was detectable in the cervical lymphocytes of the 2 smear-positive patients, but not in epithelial cells or granulocytes. HCV RNA is detectable in the CS of some HCV-seropositive women. The clinical importance of these data requires further study.

Journal Article.  4242 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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