Journal Article

Seroincidence of <i>Helicobacter pylori</i> Infection in a Cohort of Rural Bolivian Children: Acquisition and Analysis of Possible Risk Factors

M. Kathleen Glynn, Cindy R. Friedman, Benjamin D. Gold, Bhawna Khanna, Lori Hutwagner, Naomi Iihoshi, Carmen Revollo and Robert Quick

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 9, pages 1059-1065
Published in print November 2002 | ISSN: 1058-4838
Published online November 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/342910
Seroincidence of Helicobacter pylori Infection in a Cohort of Rural Bolivian Children: Acquisition and Analysis of Possible Risk Factors

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High seroprevalence rates for Helicobacter pylori are reported in developing countries, yet few seroincidence studies exist that determine age of initial acquisition and risk factors for H. pylori seroconversion. Two H. pylori serosurveys were conducted in August 1996 and November 1997. Of 188 children aged 21 months to 6 years who were seronegative in the first survey, 44 (23%) had seroconverted at follow-up, yielding an 18% annual seroincidence. The largest increase in seroincidence occurred between children aged 2 years (10%) and children aged 3 years (32%). Use of a lidded, narrow-mouthed water vessel was protective against seroconversion (odds ratio [OR], 0.3; 95% confidence interval [CI], 0.1–0.8), and the presence of another H. pylori–seropositive sibling in the household was a risk factor for seroconversion (OR, 3.1; 95% CI, 1.3–8.7). Although not a randomized intervention trial, this study suggests that the use of a narrow-mouthed water vessel may prevent the transmission of H. pylori in households in developing countries.

Journal Article.  4399 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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