Journal Article

Nosocomial Infections Occurring during Receipt of Circulatory Support with the Paracorporeal Ventricular Assist System

Armand Mekontso-Dessap, Matthias Kirsch, Emmanuelle Vermes, Christian Brun Buisson, Daniel Loisance and Rémi Houël

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 11, pages 1308-1315
Published in print December 2002 | ISSN: 1058-4838
Published online December 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/343825
Nosocomial Infections Occurring during Receipt of Circulatory Support with the Paracorporeal Ventricular Assist System

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This retrospective study sought to report the spectrum of infections in a homogenous group of 39 patients who underwent implantation of the Thoratec paracorporeal ventricular assist device system (Thoratec Laboratories) in an emergency setting. Thirty-one of the 39 patients developed a total of 99 nosocomial infections (attack rate, 79.5%; incidence, 4.9 per 100 support-days). The lungs were the most frequently involved site (31.3%), and coagulase-negative Staphylococcus species were the pathogens most frequently isolated (16.2%). Infected patients required more transfusions and chest surgical revisions, as well as a longer duration of mechanical ventilation and a longer stay in the intensive care unit, compared with uninfected patients. Cox regression analysis revealed that chest surgical revision was the only independent risk factor for infection at any site (odds ratio, 2.6; 95% confidence interval, 1.2–5.7). There was no significant effect of infection on heart transplantation rate and overall survival.

Journal Article.  4182 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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