Journal Article

Crack Cocaine Use and Other Risk Factors for Tuberculin Positivity in Drug Users

Andrea A. Howard, Robert S. Klein, Ellie E. Schoenbaum and Marc N. Gourevitch

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 10, pages 1183-1190
Published in print November 2002 | ISSN: 1058-4838
Published online November 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/343827
Crack Cocaine Use and Other Risk Factors for Tuberculin Positivity in Drug Users

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Two-step tuberculin testing and standardized interviews of 793 current and former drug users were performed to determine the risk factors for tuberculin positivity. The prevalence of tuberculin positivity was 25%. Factors independently associated with tuberculin positivity among participants seronegative for human immunodeficiency virus (HIV) included crack cocaine use (adjusted odds ratio [OR], 1.6; 95% confidence interval [CI], 1.0–2.5), employment as a home health aide (adjusted OR, 2.1; 95% CI, 1.0–4.1), birth in Puerto Rico (adjusted OR, 2.2; 95% CI, 1.3–3.6), foreign birthplace (adjusted OR, 4.7; 95% CI, 1.6–13.6), African American race (adjusted OR, 2.5; 95% CI, 1.2–5.0), reported tuberculosis exposure (adjusted OR, 2.3; 95% CI, 1.2–4.4), and older age (adjusted OR, 2.9; 95% CI, 1.2–6.7). Additional risk factors among HIV-infected participants included alcoholism (adjusted OR, 2.4; 95% CI, 1.0–5.8) and high CD4+ lymphocyte count. Identification of and administration of appropriate chemoprophylaxis to drug users with these risk factors should be given high priority.

Journal Article.  4134 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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