Journal Article

The Role of Bacterial Virulence and Host Factors in Patients with <i>Escherichia coli</i> Bacteremia Who Have Acute Cholangitis or Upper Urinary Tract Infection

Ming-Cheng Wang, Chin-Chung Tseng, Chiung-Yu Chen, Jiunn-Jong Wu and Jeng-Jong Huang

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 10, pages 1161-1166
Published in print November 2002 | ISSN: 1058-4838
Published online November 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/343828
The Role of Bacterial Virulence and Host Factors in Patients with Escherichia coli Bacteremia Who Have Acute Cholangitis or Upper Urinary Tract Infection

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We studied the pathogenic role of host and Escherichia coli virulence factors in the development of E. coli bacteremia in patients with acute cholangitis (AC) or upper urinary tract infection (UTI). Isolates recovered from 75 adult patients consecutively admitted to the hospital with E. coli bacteremia caused by AC (n = 24) or upper UTI (n = 51) were evaluated, as were 30 fecal strains isolated from healthy control individuals. Virulence genes of E. coli were detected by polymerase chain reaction analysis, including papG genes (classes I–III), sfa/foc, fimH, afa, hlyA, cnf1, and iutA. Our results show that biliary tract obstruction and urinary tract obstruction are important host factors for the development of E. coli bacteremia in patients with AC and upper UTI, respectively. With regard to E. coli virulence factors, the papG class II gene might play a more important role in the development of E. coli bacteremia in patients with upper UTI than in those with AC.

Journal Article.  3976 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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