Journal Article

γδLymphocytosis Associated with Granulomatous Disease in a Patient with Common Variable Immunodeficiency

Jean-François Viallard, Coralie Bloch-Michel, Olivier Caubet, Marie Parrens, Jeannette Texier-Maugein, Martine Neau-Cransac, Jean-Luc Taupin, Jean-François Moreau and Jean-Luc Pellegrin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 12, pages e134-e137
Published in print December 2002 | ISSN: 1058-4838
Published online December 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/344469
γδLymphocytosis Associated with Granulomatous Disease in a Patient with Common Variable Immunodeficiency

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Common variable immunodeficiency (CVID) is a heterogeneous group of immunodeficiency syndromes that involves defective production of specific antibodies and decreased serum concentrations of ⩾1 immunoglobulin isotype. We describe a patient with an atypical case of CVID who had extensive granulomatous lesions that were partially attributable to mycobacterial infection. In the peripheral blood, there was a massive increase in the number of double-negative CD3+ T cells that expressed the γδ T cell receptor.

Journal Article.  2053 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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