Journal Article

Prospective Immunogenicity Study of Multiple Intradermal Injections of Rabies Vaccine in an Effort to Obtain an Early Immune Response without the Use of Immunoglobulin

Pakamatz Khawplod, Henry Wilde, Saovaluk Tepsumethanon, Sukunya Limusanno, Tanpetch Tantawichien, Pranee Chomchey, Ampai Bungjongkasaena Na Ayuthaya and Yongyuth Wangroonsarb

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 35, issue 12, pages 1562-1565
Published in print December 2002 | ISSN: 1058-4838
Published online December 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/344954
Prospective Immunogenicity Study of Multiple Intradermal Injections of Rabies Vaccine in an Effort to Obtain an Early Immune Response without the Use of Immunoglobulin

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The present study sought to determine whether increasing and accelerating rabies vaccine administration would result in earlier protective levels of neutralizing antibody. Results indicated that the 8-site and double-dose Thai Red Cross intradermal regimens produced higher antibody titers by day 14 but not significantly higher titers by days 5 and 7. Administration of rabies immunoglobulin into and around bite wounds on the first day of rabies prophylaxis should remain the optimal postexposure treatment.

Journal Article.  1902 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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