Journal Article

Cluster of Cases of Acute Hepatitis Associated with Hepatitis E Virus Infection Acquired in The Netherlands

Marc-Alain Widdowson, Wim J. M. Jaspers, Wim H. M. van der Poel, Froukje Verschoor, Ana Maria de Roda Husman, H. L. J. Winter, Hans L. Zaaijer and Marion Koopmans

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 1, pages 29-33
Published in print January 2003 | ISSN: 1058-4838
Published online January 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/345439
Cluster of Cases of Acute Hepatitis Associated with Hepatitis E Virus Infection Acquired in The Netherlands

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Increasing evidence suggests that hepatitis E virus (HEV) infection may occur in developed countries and that swine may act as a reservoir. We report a cluster of 2 confirmed cases and 1 presumptive case of hepatitis associated with HEV. The typed strain from 1 case was related to HEV strains found in North America and Europe, and it was also related to a cluster of swine HEV strains found in The Netherlands. Our findings indicate that locally acquired HEV infections in industrialized countries may be overlooked. Routine testing for HEV infection in patients with acute hepatitis in The Netherlands should be considered before a diagnosis of autoimmune hepatitis is reached and steroid therapy is initiated.

Journal Article.  3003 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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