Journal Article

A Prospective Study of Genital Herpes Simplex Virus Type 2 Infection in Human Immunodeficiency Virus Type 1 (HIV-1)–Seropositive Women: Correlations with CD4 Cell Count and Plasma HIV-1 RNA Level

Patty W. Wright, Craig J. Hoesley, Kathleen E. Squires, Angela Croom-Rivers, Heidi L. Weiss and John W. Gnann

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 2, pages 207-211
Published in print January 2003 | ISSN: 1058-4838
Published online January 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/345440
A Prospective Study of Genital Herpes Simplex Virus Type 2 Infection in Human Immunodeficiency Virus Type 1 (HIV-1)–Seropositive Women: Correlations with CD4 Cell Count and Plasma HIV-1 RNA Level

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A cohort of 217 human immunodeficiency virus type 1 (HIV-1)–seropositive women was observed prospectively from 1996 through 2000 to determine the frequency of genital herpes simplex virus type 2 (HSV-2) disease (symptomatic and asymptomatic) and to correlate those findings with HIV-1–related immunosuppression (absolute CD4 cell counts and plasma HIV-1 RNA levels). Participants underwent twice-yearly pelvic examinations, including cultures of cervicovaginal specimens and swab specimens from genital lesions, if lesions were present. Of the participants, 72 (33%) had genital HSV-2 infection diagnosed on the basis of either history alone (23 [32%]) or positive culture results (49 [68%]). The 72 women who had genital herpes diagnosed completed 242 total visits. Of these visits, positive HSV-2 culture results were noted at 80 (33%); at 23 (29%) of the 80 visits at which there were HSV-2–positive cultures, culture results were not associated with a clinically apparent genital lesion. Positive HSV-2 culture results occurred more frequently for samples obtained from patients with higher plasma HIV-1 RNA levels (P =.019) and lower CD4 cell counts (P <.001).

Journal Article.  2688 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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