Journal Article

Human Herpesvirus 6B Infection of the Large Intestine of Patients with Diarrhea

Kiyoko Amo, Keiko Tanaka-Taya, Reiko Inagi, Hiromi Miyagawa, Hiroko Miyoshi, Ikuko Okusu, Junji Sashihara, Junichi Hara, Masahiro Nakayama, Koichi Yamanishi and Shintaro Okada

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 1, pages 120-123
Published in print January 2003 | ISSN: 1058-4838
Published online January 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/345464
Human Herpesvirus 6B Infection of the Large Intestine of Patients with Diarrhea

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Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.

Journal Article.  2006 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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