Journal Article

Epidemic Rift Valley Fever in Saudi Arabia: A Clinical Study of Severe Illness in Humans

Mohammed Al-Hazmi, Ephraim Ayobanji Ayoola, Mahmoud Abdurahman, Subodh Banzal, Jammal Ashraf, Adil El-Bushra, Ali Hazmi, Mohammed Abdullah, Hamid Abbo, Abdulhadi Elamin, El-Tayeb Al-Sammani, Mohammed Gadour, Chandra Menon, Mirghani Hamza, Inam Rahim, Magdy Hafez, Manish Jambavalikar, Haider Arishi and Ali Aqeel

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 3, pages 245-252
Published in print February 2003 | ISSN: 1058-4838
Published online February 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/345671
Epidemic Rift Valley Fever in Saudi Arabia: A Clinical Study of Severe Illness in Humans

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We describe the clinical patterns and case-fatality rate associated with severe Rift Valley fever (RVF) in patients who were admitted to the Gizan regional referral hospital during an outbreak of RVF in Saudi Arabia from September through November 2000. A total of 165 consecutive patients (136 men and 29 women) were prospectively studied; all were identified according to a strict case definition, were confirmed to have RVF by serologic testing, and were treated according to a predetermined protocol. The major clinical characteristics of RVF included a high frequency of hepatocellular failure in 124 patients (75.2%), acute renal failure in 68 patients (41.2%), and hemorrhagic manifestations in 32 patients (19.4%). Sixteen patients had retinitis and 7 patients had meningoencephalitis as late complications in the course of the disease. A total of 56 patients (33.9%) died. Hepatorenal failure, shock, and severe anemia were major factors associated with patient death.

Journal Article.  4601 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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