Journal Article

Severe Prolonged Red Blood Cell Aplasia and Thrombocytopenia Induced by Parvovirus B19 Infection in a Patient with Sarcoidosis

Jean-François Viallard, Marie Parrens, Olivier Hermine, Jean-Michel Boiron, Marie-Edith Lafon, Gérald Marit, Josy Reiffers and Jean-Luc Pellegrin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 2, pages 229-233
Published in print January 2003 | ISSN: 1058-4838
Published online January 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/345745
Severe Prolonged Red Blood Cell Aplasia and Thrombocytopenia Induced by Parvovirus B19 Infection in a Patient with Sarcoidosis

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We describe an acromegalic patient who developed a parvovirus B19 (PVB19) infection concomitantly with sarcoidosis, which was complicated by chronic red blood cell aplasia and severe thrombocytopenia, despite disappearance of the virus from serum and the production of high levels of specific polyclonal antibodies to PVB19. Mitogen stimulation of the patient's peripheral blood mononuclear cells induced oversecretion of interferon-γ (IFN-γ). Because hematopoietic suppression by IFN-γ has been reported, a possible mechanism underlying reticulocytopenia and thrombocytopenia could involve IFN-γ.

Journal Article.  2517 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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