Journal Article

Susceptibility of Antimicrobial-Resistant Urinary <i>Escherichia coli</i> Isolates to Fluoroquinolones and Nitrofurantoin

James A. Karlowsky, Clyde Thornsberry, Mark E. Jones and Daniel F. Sahm

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 2, pages 183-187
Published in print January 2003 | ISSN: 1058-4838
Published online January 2003 | e-ISSN: 1537-6591 | DOI:
Susceptibility of Antimicrobial-Resistant Urinary Escherichia coli Isolates to Fluoroquinolones and Nitrofurantoin

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In vitro surveillance data from across the United States indicate that ∼10%–20% of urinary Escherichia coli isolates from female outpatients are resistant to trimethoprim-sulfamethoxazole (TMP-SMX). Alternative therapies for uncomplicated urinary tract infections in women include fluoroquinolones and nitrofurantoin, but the activities of these agents against TMP-SMX–resistant isolates are rarely reported. Among TMP-SMX–resistant urinary E. coli isolates tested in US laboratories from 1998 through 2001, 9.5% (5767 of 60,414) were resistant to ciprofloxacin and 1.9% (1214 of 63,817) were resistant to nitrofurantoin; 10.4% of ciprofloxacin-resistant isolates (683 of 6560) were resistant to nitrofurantoin. An association between resistance to fluoroquinolones and nitrofurantoin in E. coli has not been previously reported and warrants further study.

Journal Article.  2312 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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