Journal Article

Fluoroquinolone Resistance in <i>Streptococcus pyogenes</i>

Sandra S. Richter, Daniel J. Diekema, Kris P. Heilmann, Laurel S. Almer, Virginia D. Shortridge, Rod Zeitler, Robert K. Flamm and Gary V. Doern

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 3, pages 380-383
Published in print February 2003 | ISSN: 1058-4838
Published online February 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/345904
Fluoroquinolone Resistance in Streptococcus pyogenes

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Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 μg/mL) was found. DNA amplification and sequencing revealed a serine81→tyrosine substitution in gyrA and 2 substitutions in parC: serine79→phenylalanine and alanine121→valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.

Journal Article.  2839 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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