Journal Article

Human Immunodeficiency Virus Type 1-Related Lipoatrophy and Lipohypertrophy Are Associated with Serum Concentrations of Leptin

G. Sonia Nagy, Sotirios Tsiodras, Lizabeth D. Martin, Anchalee Avihingsanon, Alina Gavrila, William C. Hsu, Adolf W. Karchmer and Christos S. Mantzoros

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 6, pages 795-802
Published in print March 2003 | ISSN: 1058-4838
Published online March 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/367859
Human Immunodeficiency Virus Type 1-Related Lipoatrophy and Lipohypertrophy Are Associated with Serum Concentrations of Leptin

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The relationship between the adipocyte-derived hormone leptin, insulin resistance, and fat redistribution in patients with human immunodeficiency virus (HIV) infection has not been established. We classified a cohort of HIV type 1 (HIV-1)-infected patients with ∼6 months of antiretroviral exposure as having no lipodystrophy (51 patients [43% of the cohort]), lipoatrophy (23 patients [19% of the cohort]), mixed lipodystrophy (29 patients [24% of the cohort]), or lipohypertrophy (17 patients [14% of the cohort]), on the basis of physical examination, anthropometric measurements, and the findings of dual-emission x-ray absorptiometry and computed tomography. Measurements of insulin resistance were higher for patients with each category of lipodystrophy, compared with those observed for patients with no lipodystrophy (P <.001). Mean leptin levels (± standard deviation) were lowest in patients with lipoatrophy (1.76 ± 1.20 ng/mL), highest in patients with lipohypertrophy (9.10 ± 6.86 ng/mL), and significantly different from those in patients without lipodystrophy (3.14 ± 2.30 ng/mL; both P <.01). In this cohort of antiretroviral-experienced HIV-infected patients, a low serum level of leptin was independently associated with insulin resistance in patients with lipoatrophy, after controlling for total and regional body fat.

Journal Article.  4981 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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