Journal Article

Encephalitis Associated with Influenza B Virus Infection in 2 Children and a Review of the Literature

Jason G. Newland, José R. Romero, Meera Varman, Casey Drake, Amy Holst, Tom Safranek and Kanta Subbarao

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 7, pages e87-e95
Published in print April 2003 | ISSN: 1058-4838
Published online April 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/368184
Encephalitis Associated with Influenza B Virus Infection in 2 Children and a Review of the Literature

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Two children with influenza B-associated encephalitis (IBAE) presented to our hospital during the winter of 2000–2001, both of whom had cases notable for mutism in association with encephalitis. A review of the literature identified 13 additional reports consistent with IBAE that contained sufficient data for analysis. Eleven of 15 reported cases occurred in children aged ⩽18 years; of these, more than one-half occurred in children <11 years of age. Neurologic symptoms appeared within the first 4 days of illness in 13 cases. Speech abnormalities were observed in 4 patients and consisted of mutism in 3. Although the majority of patients recovered fully, 3 were left with neurologic sequelae, and 1 died. These cases reveal the spectrum of IBAE and its potential for long-term sequelae. Clinicians caring for children should remain vigilant for this rare complication of influenza B virus infection.

Journal Article.  4136 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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