Journal Article

Risk Factors for Pediatric Ventriculoperitoneal Shunt Infection and Predictors of Infectious Pathogens

Matthew J. McGirt, Aimee Zaas, Herbert E. Fuchs, Timothy M. George, Keith Kaye and Daniel J. Sexton

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 7, pages 858-862
Published in print April 2003 | ISSN: 1058-4838
Published online April 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/368191
Risk Factors for Pediatric Ventriculoperitoneal Shunt Infection and Predictors of Infectious Pathogens

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Identification of risk factors for shunt infection and predictors of infectious pathogens may improve current methods to prevent and treat shunt infections. We reviewed data on 820 consecutive ventriculoperitoneal (VP) shunt placement procedures in 442 pediatric patients at our institution during 1992–1998. Ninety-two shunts (11%) developed infection a median of 19 days (interquartile range, 11–35 days) after insertion. Premature birth (relative risk [RR], 4.81; 95% confidence interval [CI], 2.19–10.87), previous shunt infection (RR, 3.83; 95% CI, 2.40–6.13), and intraoperative use of the neuroendoscope (RR, 1.58; 95% CI, 1.01–2.50) were independent risk factors for shunt infection. The bacterial organisms early after shunt surgery (<14 days) were the same as those late after shunt surgery (>14 days). As determined by an analysis of the 92 infected shunts, hospital stay of >3 days at the time of shunt insertion (odds ratio [OR], 5.27; 95% CI, 1.15–25.3) and prior Staphylococcus aureus shunt infection (OR, 5.91; 95% CI, 1.35–25.9) independently increased the odds that S. aureus was the causal pathogen.

Journal Article.  3382 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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