Journal Article

Acquired T-helper 1 Lymphocyte Anergy Following Infection with <i>Mycobacterium ulcerans</i>

Travis M. Gooding, Andrew S. Kemp, Roy M. Robins-Browne, May Smith and Paul D. R. Johnson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 8, pages 1076-1077
Published in print April 2003 | ISSN: 1058-4838
Published online April 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/368315
Acquired T-helper 1 Lymphocyte Anergy Following Infection with Mycobacterium ulcerans

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We describe a patient with acquired T-helper lymphocyte anergy to mycobacteria following infection with Mycobacterium ulcerans. Before infection, the patient's peripheral blood mononuclear cells responded to in vitro stimulation with M. ulcerans by producing Th1 cytokines, but, after she developed an ulcer, the response was shifted toward production of Th2 cytokines. Immunomodulatory therapy may be an effective intervention for Buruli ulcer.

Journal Article.  1331 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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