Journal Article

Contamination of Bone Marrow Products with an Actinomycete Resembling <i>Microbacterium</i> Species and Reinfusion into Autologous Stem Cell and Bone Marrow Transplant Recipients

Zahir Hirji, Ronnie Saragosa, Heln Dedier, Michael Crump, Norman Franke, Lori Burrows, Frances Jamieson, Shirley Brown and Michael A. Gardam

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 10, pages e115-e121
Published in print May 2003 | ISSN: 1058-4838
Published online May 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374051
Contamination of Bone Marrow Products with an Actinomycete Resembling Microbacterium Species and Reinfusion into Autologous Stem Cell and Bone Marrow Transplant Recipients

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Bacterial contamination of bone marrow or peripheral blood stem cell transplant products typically occurs with skin flora or, rarely, gram-negative organisms. We describe a clonal outbreak of contamination in transplant products caused by contamination with an aerobic actinomycete that occurred at our institution during the summer of 2001. From 1 July through 12 September 2001, 73 peripheral blood or bone marrow stem cell products were obtained from 39 patients, and 34 products were found to be contaminated with the outbreak strain. Fourteen patients were reinfused with contaminated cells, and the outbreak strain was isolated from the blood cultures for one patient. Investigation revealed multiple potential sources for contamination during the product cryopreservation process. The outbreak of contamination was aborted upon modification of the cryopreservation process.

Journal Article.  3499 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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