Journal Article

Treatment of Multidrug-Resistant Tuberculosis during Pregnancy: A Report of 7 Cases

Sonya Shin, Dalia Guerra, Michael Rich, Kwonjune J. Seung, Joia Mukherjee, Keith Joseph, Rocio Hurtado, Felix Alcantara, Jaime Bayona, Cesar Bonilla, Paul Farmer and Jennifer Furin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 8, pages 996-1003
Published in print April 2003 | ISSN: 1058-4838
Published online April 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374225
Treatment of Multidrug-Resistant Tuberculosis during Pregnancy: A Report of 7 Cases

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Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem affecting women of childbearing age. Little is known, however, about the safety of the drugs used to treat MDR-TB during pregnancy. We describe 7 patients who were treated for MDR-TB during pregnancy. These patients had chronic tuberculosis that had caused extensive parenchymal damage and had high-grade resistance to antituberculous drugs. All patients received individualized antituberculous therapy prior to delivery of healthy term infants. Neither obstetrical complications nor perinatal transmission of MDB-TB was observed. One patient experienced treatment failure, and another abandoned therapy. The other 5 patients are currently cured or in treatment and have culture-negative status. In each of these 7 cases, excellent treatment outcomes were obtained for the women and their children. Under certain circumstances, MDR-TB can be successfully treated during pregnancy.

Journal Article.  4877 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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