Journal Article

Efficacy of a Targeted, Oral Penicillin—Based Yaws Control Program among Children Living in Rural South America

D. Scolnik, L. Aronson, R. Lovinsky, K. Toledano, R. Glazier, J. Eisenstadt, P. Eisenberg, L. Wilcox, R. Rowsell and M. Silverman

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 10, pages 1232-1238
Published in print May 2003 | ISSN: 1058-4838
Published online May 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374338
Efficacy of a Targeted, Oral Penicillin—Based Yaws Control Program among Children Living in Rural South America

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Yaws is endemic in rural Guyana. An observational study was conducted to determine the efficacy of oral penicillin V therapy in treating skin lesions of yaws in children. In 1999, inhabitants of 7 rural villages near Bartica, Guyana, were screened for skin lesions of yaws. Cases were confirmed by serological testing. A control program was implemented in 2000: children ⩽14 years old were screened, and those with active lesions were treated with oral penicillin V for 7–10 days. In 2001, children were rescreened and active cases were treated. Prevalence of yaws skin lesions fell from 5.1% (52 of 1020 children screened in 2000) to 1.6% (8 of 516 in 2001), a 71% drop. Sixteen (94%) of 17 children treated in 2000 and reassessed in 2001 had complete resolution of lesions. A targeted, oral penicillin-based treatment regimen can successfully treat dermatologic yaws in individual children and can decrease the prevalence of skin yaws in a community in which it is endemic. This information may aid in the implementation of additional control efforts.

Journal Article.  3165 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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