Journal Article

Incidence of Acquired Immunodeficiency Syndrome-Associated Opportunistic Diseases and the Effect of Treatment on a Cohort of 1115 Patients Infected with Human Immunodeficiency Virus, 1989–1997

Francisco-Javier San-Andrés, Rafael Rubio, Jesús Castilla, Federico Pulido, Guillermo Palao, Inmaculada de Pedro, José-Ramón Costa and Angel del Palacio

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 9, pages 1177-1185
Published in print May 2003 | ISSN: 1058-4838
Published online May 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374358
Incidence of Acquired Immunodeficiency Syndrome-Associated Opportunistic Diseases and the Effect of Treatment on a Cohort of 1115 Patients Infected with Human Immunodeficiency Virus, 1989–1997

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Temporal trends in the incidence of opportunistic diseases (ODs) related to acquired immunodeficiency syndrome (AIDS) were studied during 1989–1997 in 1115 outpatients infected with human immunodeficiency virus (331 of whom had AIDS) in a hospital in Madrid, Spain. We analyzed the effect of adherence to antiretroviral therapy and Pneumocystis carinii pneumonia (PCP) prophylaxis on the incidence of OD. Diseases that showed a significant decreasing trend were esophageal candidiasis, pulmonary and extrapulmonary tuberculosis, and cerebral toxoplasmosis. Patients who adhered to antiretroviral therapy had a smaller risk of OD. Patients who adhered to PCP prophylaxis had a reduced risk of cerebral toxoplasmosis and PCP. A reduction in the incidence of AIDS-related ODs was observed, mainly in patients who underwent prophylaxis. Adherence to antiretroviral treatment and PCP prophylaxis was associated with a reduction in the risk of disease.

Journal Article.  4434 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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